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The association of PBRM1 downregulation with increased aggressive tumor behavior might have therapeutic impact, particularly for those patients representing organ-confined ccRCC at diagnosis. To validate this hypothesis, it will be essential to test PBRM1 tumor-suppressive functions in animal models. The identification of oncogenic pathways controlled by PBRM1 may provide novel targeted therapeutic approaches in RCC. The authors thank Martina find more Storz and Andr�� Fitsche for technical assistance. This work was funded by the Swiss National Science Foundation and the Zurich Cancer League (H.M.). R.P. is supported by postdoctoral fellowship from the European Molecular Biology Organization (EMBO). ""Chronic myeloid Palbociclib mw leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months. The outcome was analyzed for 42 patients with lymphoid BP-CML who were treated with hyperfractionated cyclophosphamide, vincristine, Adriamycin, dexamethasone (HCVAD) plus imatinib or dasatinib. Complete hematological response was achieved in 90% of patients, complete cytogenetic remission in 58%, and complete molecular remission in 25%. Flow cytometry minimal residual disease negativity was achieved by 42% of evaluable patients after induction. Eighteen patients received allogeneic stem cell transplant (SCT) while in first complete hematological response. Median remission duration was 14 months and was longer among SCT recipients (P?=?.01) on multivariate analysis. Median overall survival was 17 months (range, 7-27 months) and was longer among SCT recipients (P?<?.001) and patients treated with dasatinib (P?=?.07) on multivariate analysis. Although a high rate of hematologic toxicity (100%) <a href="https://en.wikipedia.org/wiki/Heptaminol">heptaminol and infectious complications (59%) were observed, the related rate of treatment discontinuation was low (7% and 9%, respectively). HCVAD combined with tyrosine kinase inhibitors is an effective regimen for the management of BP-CML, particularly when followed by allogeneic SCT. Cancer 2014;120:373�C380 ? 2013 American Cancer Society. ""The purpose of this study was to investigate the value of post-operative radiotherapy in the treatment of pT3N0M0 breast cancer after mastectomy. We analyzed the clinical data of 1390 patients with pT1-3N0M0 breast cancer who were admitted and treated from 1998 to 2007 at the Sun Yat-sen University Cancer Center. All patients underwent mastectomy and did not receive radiotherapy. The locoregional recurrence-free survival, distant metastasis-free survival and overall survival of different T stages of breast cancer were compared. The median follow-up duration was 72?months. The 10-year locoregional recurrence-free survival patients with pT1N0, pT2N0 and pT3N0 breast cancers were 95.3, 91.9 and 93.6%, respectively (��2?=?2.550, P?=?0.279).