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7% and 90% in July and then to 57.1% and 70% in August for, respectively, the Adults and Maiden females. Overall, the experimental period, 92.5% and 83.8% of Adult and Maiden ewes ovulated at least once per month (p?<?0.01) respectively. Least proportions ovulating, attained 60% and 30% in April for, respectively, Adult and Maiden ewes before peaking up at 100% again in May (p?<?0.05). Mean (��SD) ovulation rate of Sicilo-Sarde sheep is 1.40?��?0.503. Adult females had a higher (p?<?0.001) ovulation rate than Maiden sheep with respective average values of 1.51?��?0.516 and 1.16?��?0.373. It varied little between months and decreased in Adults from a maximum value of <a href="https://en.wikipedia.org/wiki/RecBCD">RecBCD 1.95 in October to a minimum value of 1.16 in April. It is concluded that benchmarking seasonal variations of reproductive activity in Sicilo-Sarde breed would be valuable in designing improved management calendars for this breed. ""The study examined articular and growth plate cartilages as well as bone tissues in the offspring of sows treated with glucocorticoid during the last 45?days of pregnancy (dexamethasone at the dose of 0.03?mg/kg body weight intramuscularly, every second day). The offspring were tested at the birth and basal morphology for both articular and growth plate cartilages, and the histomorphometry of trabeculae of the epiphysis Anti-diabetic Compound Library high throughput and metaphysis of femur and tibia were established. The concentration of selected cytokines and the activity of bone alkaline phosphatase were determined in blood serum. Maternal dexamethasone (DEX) administration reduced the thickness of proliferative, resting and hypertrophic zones of growth plate of femur and tibia of male piglets when compared with the control. DEX significantly reduced the thickness of the resting zone in both bones. It also elongated check details proliferative and hypertrophic zones of the growth plate in the femur as well as the hypertrophic zone in the tibia of female piglets when compared with the control group. Moreover, DEX decreased the articular cartilage thickness of the tibia in female piglets and enhanced the articular cartilage thickness of the femur in male piglets. Articular cartilage was highly cellular, and chondrocytes were separated by thin septa of matrix. An analysis of the trabecular bone architecture in male piglets showed a loss of the trabecular bone by thinning and DEX-related increase in trabecular porosity. Moreover, the cortical bone looked similar to the trabeculae because of trabecularization of the cortex. There was a DEX that reduced serum osteocalcin and BAP concentrations in both female and male newborn piglets, whereas the serum IL-1 and Il-6 was reduced only in male piglets. The obtained results demonstrated that DEX administration to sows during the last 45?days of pregnancy might cause the growth to slow and eventually to stop, especially in male piglets. It might lead to an alteration within the cartilage during its normal function, and with the time, arthritic changes can follow.